Endocrine Abstracts

Obesity is thought to be a main risk factor of insulin resistance and diabetes mellitus. Study on concentrations of lipids in the tissues of animals with experimental model of obesity resulting in insulin resistance remains currently central. The work was initiated to study the spectrum of lipids and their concentrations in the tissues of experimental animals with the induced alimentary obesity.Alimentary obesity with concurrent insulin resistance was in...

Members of the Euphorbia L. genus have been used both in both traditional and alternative medicine for treatment of a wide range of disorders since time immemorial. Due to a wide spectrum of compounds of phoyphenolic nature, they are known to show anti-oxidant, anti-inflammatory, antimicrobial, fungicidal and antileukemic effects. The work was initiated to study a hypoglycemic effect of polyphenolic compounds isolated from two types of the Euphorbia L. genus. Polyphen...

Physiological role of nerve growth factor (NGF) was characterized for the sensory and vegetative nervous systems, as well as for the central, endocrine and immune systems. The growth simulator and a cytokine, NGF is known to be involved in the metabolism of various pathological conditions. Recent clinical and academic studies among patients with diabetes mellitus, insulin resistance and Alzheimer’s disease have brought to light previously unreported cell and pathological ...

Alzheimer’s disease is closely associated with type 2 diabetes mellitus (DM); being considered as type 3 DM due to common molecular peculiarities of type 2 DM and insulin resistance associated with the memory deficit and decline in the cognitive functions in elderly persons. We generated a model of sporadic neurodegenerative condition (NDC) or type 3 DM. The work was initiated to study profile of phospholipids in the hippocampal membranes of rats with the induced sporadic...

Phytotherapy is the integral part of the combined treatment for diabetes mellitus. A large number of plants possessing hypoglycemic activity are described in the literature, but only small part of them is in use. Hypoglycemic effect of medicinal plants is preconditioned by the wide spectrum of compounds with biological activity in their composition. Flowers of carthamus (Carthamus tinctorius) and leaves of celery (Apium graveolens) are known to possess a numb...

Backgrounds: Diabetes mellitus is a complex disease accompanied by the development of complications. In addition to the classic hyperglycemia and dyslipidemia, a number of other factors are involved in the pathogenesis of complications. Plasmalogens disturbances participates in nerve tissue degeneration.Materials and methods: In 76 people with DM2 plasma and erythrocytes membranes plasmalogenes measured and compared according to diabetic neuropathy.<...

Causing production of free radicals and reduction of antioxidant system activity, in the pancreatic β-cells, in particular, resulting in reduction in insulin production and consequently to hyperglycemia, oxidative stress could be a pathogenetic mechanism of morbidity in diabetes mellitus. Search for and development of medicines with antioxidant and hypoglycemic activity remains urgent.Aim: The work was initiated to study antioxidant and hypoglycemic...

Obesity is considered as a major factor of insulin resistance and diabetes mellitus risk. Study on lipid composition of tissues in obesity is relevant in understanding of mechanisms underlying insulin resistance.Aim: The work was initiated to study lipid composition of liver and skeletal muscles tissues in rats with alimentary obesity.Materials and methods: Obesity was induced in rats leading an inactive lifestyle with prolonged hi...

Prevention of familial diabetes mellitus is a most urgent problem in diabetology. Genetic susceptibility is a leading factor in diabetes mellitus onset.Aim: The work was initiated to assess potentiality of diabetes mellitus risk prediction based on genealogical analysis.Materials and methods: For the purpose of the study, 53 patients with diabetes mellitus were examined. The probands’ mean age was 14.4 years. Genealogical medi...

Aim: The work was initiated to study TNF-α gene polymorphism and parameters of oxidative stress in patients with type 2 diabetes mellitusMaterials and methods: We examined 41 healthy subjects and 20 patients with diabetes mellitus to study G308A (rs1800629) polymorphism in TNF-α gene by means of allele-specific PCR method (AS-PCR). Rates of lipid peroxidation (LP) were determined by concentration of malon dialdehyde (MDA); catalase activity was...